Khasiat Jamu Antidiabetes pada Tikus Sprague Dawley yang Diinduksi Streptozocin
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Antidiabetes, Glukosa darah, HbA1C, JAMSI
Abstract
Penelitian ini bertujuan untuk membuktikan khasiat JAMSI, Jamu antidiabetes PT. Mahkotadewa Indonesia, secara preklinis pada tikus diabetes yang diinduksi dengan streptozotocin. Tikus jantan Sprague Dawley sebanyak 36 ekor dibagi secara acak menjadi 6 kelompok (masing-masing kelompok 6 tikus): kelompok normal, kelompok kontrol diabetes (diinduksi + air saline), kelompok kontrol positif (diinduksi + Glibenclamide 2.5 mg/kg BB), dan tiga kelompok perlakuan (diinduksi + JAMSI dengan dosis 0.27, 0.81, dan 1.62 ml/kg BB). Perlakuan diberikan selama 28 hari setelah diinduksi dengan streptozotocin. Pemberian JAMSI 1.62 ml/kg BB terbukti mempengaruhi penurunan kadar glukosa darah dan hemoglobin terglikosilasi (HbA1C) dibandingkan kelompok diabetes. Hasil ini mengindikasikan bahwa JAMSI berkhasiat sebagai antidiabetes.
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