Antioxidant and Sunscreen Activity from Nanoparticles Extract of Temulawak Rhizome (Curcuma Xanthorrhiza Roxb.) And Formulation in The Form of A Cream
Article Sidebar
-
Kata kunci: Rimpang Temulawak, Nanopartikel, Antioksidan, Nilai SPF
Abstract
Temulawak (Curcuma xanthorrhiza Roxb.) is a medicinal plant for the raw material of traditional medicine in Indonesia. Temulawak can be a source of antioxidants and natural sunscreen because of its curcumin content. This study was conducted to determine antioxidant and sunscreen activity on Curcuma rhizome extract and nanoparticles extract and making cream preparations. Extraction using the maceration methods with 96% ethanol solvent, concentrated with a rotary evaporator and the thick extract of Curcuma rhizome was made into nanoparticles by ionic gelation methods. Spray drying methods dried the nanosuspension of Curcuma rhizome extract. The nanoparticles formed were evaluated for particle size, zeta potential and particle morphology. The dry powder nanoparticles and extract of Curcuma rhizome were tested for antioxidant activity by DPPH (2,2-diphenyl-1-picrylhydrazyl) methods and sunscreen using a UV-Vis spectrophotometer at λ = 290-340 nm. The antioxidant activity showed the IC50 value of the Curcuma rhizome extract was 78.30 μg/mL and nanoextract was 116.51 μg/mL. The sunscreen testing result showed that the SPF (Sun Protective Factor) value of Curcuma rhizome extract at a concentration of 0,012% was 14.14 and nanoextracts at a concentration of 0.04% was 7.73. Curcuma rhizome extract has relatively strong antioxidant activity, while the nanoextract was moderate. The sunscreen activity of Curcuma rhizome extract and nanoextract has maximum protection and extra protection.
Full text article
References
Anggoro D, Rajian SR, Siswarni MZ. 2015. Ekstraksi multi tahap kurkumin dari temulawak (Curcuma xanthorriza Roxb.) menggunakan pelarut etanol. Jurnal Teknik Kimia USU. 4(2): 43.
Anonim. 2010. Zetasizer nano ZS training course. UK: Malvern. 1-120 p.
Azzahra RK. 2017. Kulit sehat dimulai dari kadar pH yang tepat. Diakses dari https://journal.sociolla.com/beauty/ph-kulit-wajah/ pada tanggal 27 Juli 2021.
Bhumkar DR and Pokhharkar VB. 2006. Study on effect of pH on cross linking of chitosan with sodium tripoliphosphate: a technical note. J Pharm Sci Techno. 2: 1-6.
Dhase, A. S., Khadbadi, S. S., & Saboo, S. S. (2014). Formulation and evaluation of vanishing herbal cream of crude drugs. AJEthno, 1, 313-8.
Ekowati, D. & Hanifah, I. R. (2017). Potensi tongkol jagung (Zea Mays L.) sebagai sunscreen dalam sediaan hand body lotion. Jurnal Ilmiah Manuntung, 2(2), 198-207.
Food and Drug Administration (FDA). Diakses dari https://www.fda.gov/news-events/press-announcements/fda-advances-new-proposed-regulation-make-sure-sunscreens-are-safe-and-effective pada tanggal 27 Juli 2021.
Hidayanti I. 2019. Formulasi nanopartikel ekstrak kering rimpang temulawak (Curcuma xanthorrhiza Roxb.) dengan metode gelasi ionic dan uji aktivitas antioksidan. Fakultas Farmasi Universitas Pancasila, Jakarta.
Jun M, Fu HY, Hong J, et al. 2003. Comparison of antioxidant activities of isoflavones fromkudzu root (Pueraria lobata Ohwi). J food Sci. 68(6):2117-22
Kaur CD, Saraf S. 2010. In vitro sun proctection factor determination of herbal oils used in cosmetics. Pharmacognosy research. 2(1):22-25.
Kemenkes RI. 2008. Farmakope herbal Indonesia. Edisi 1. Departemen Kesehatan republik Indonesia.
Marliani L., Nastiti AD., Roni A. 2015. Aktivitas antioksidan dan tabir surya ekstrak rimpang Curcuma domestica Val., Curcuma xanthorrhiza Roxb. dan Curcuma manga Val. {skripsi}. Bandung: Fakultas Farmasi, Universitas Jenderal Achmad Yani.
Mitsui T. 1997. New cosmetic science. New York (NY): Elsevier Science.
Murdock, R.C., Braydich-Stole, L., Schrand, A.M., et al. 2008. Characterization of nanoparticle dispersion in solution prior to in vitro exposure using dynamic light scattering echnique. Toxicol, Sci, 101: 239-253.
Prasiddha IJ, Rosalina AL, Teti Estiasih, Jaya MM. Potensi senyawa bioaktif rambut jagung (Zea mays L.) untuk tabir surya alami: kajian pustaka. Jurnal Pangan dan Argoindustri. 2016; 4(1): h 40-45.
Rowe RC, Sheskey P., Owen SC. 2006. Handbook of pharmaceutical excipient. 5th Edition. London: Pharmaceutical Press and American Pharmacist Assosiation.
Santos Nogueira AC, Joekes I. 2004. Hair color changes and protein damage cause by ultraviolet radiation. J Photochem Photobiaol B. 74(2-3):109-117.
Sidik, Mulyono MW, Muhtadi A. 1985. Temulawak (Curcuma xanthorriza Roxb.). Yayasan Pengembangan Obat Bahan Alam Phytomedica. Jakarta.
Syamarlina, Rahmat D, Deny W. 2019. Formulasi nanopartikel ekstrak temulawak berbasis kitosan sebagai antijerawat. Medica Sains: Jurnal Ilmu Kefarmasian. 3(2):153-157.
Wang, X, na Chi, Xian T. 2008. Preparation of estradiol chitosan nanoparticles for improving nasal absorption and brain targeting. European Journal of Pharmaceuticals and Biophamaceutics. 70(3):735-740.
Authors
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Copyright @2017. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted non-commercial used, distribution and reproduction in any medium