Effect of Seaweed Ethanol Extract on Cholesterol Levels and Obesity in White Rats
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Seaweed ethanol extract, Hypocholesterolemia, Antiobesity, High fat diet
Abstract
Seaweed (EucheumaCottonii J. Agardh) is one of the biological resources found in coastal and marine areas. Seaweed contains secondary metabolites such as flavonoids, alkaloids, polyphenols and tannins which can reduce cholesterol levels in the blood. This study aims to determine the effect of seaweed ethanol extract on reducing cholesterol and obesity levels by comparing plasma cholesterol levels, body weight, and weight of vital organs (liver, kidneys and jantumg) of obese rats, mice given seaweed ethanol extract with normal mice . Rats were grouped randomly into 6 groups. group one was given 0.5% CMC Na, group two was given high fat diet food, group three was given simvastatin, group four was given seaweed ethanol extract 100 mg / kgbb, group five was given ethanol extract of seaweed 200 mg / kgbb and group six was given ethanol extract of seaweed 300 mg / kg with a long suspension of extract for 14 days. Measurement of cholesterol levels in the blood using the CHOD-PAP method, body weight and organs carried out by weighing. The results showed that seaweed ethanol extract has the effect of inhibiting an increase in plasma cholesterol levels and has anti-obesity potential at a dose of 300 mg / kgbb.
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References
Artha C, Mustika A, & Sulistyawati SW. 2017. Pengaruh Ekstrak Daun Singawalang terhadap Kadar LDL Tikus Putih Jantan Hiperkolesterolemia Singawalang Leaf Extract Effects on LDL Levels of Hypercholesterolemic Male Rats. Ejki Journal. 5(2): 105–109.
Awang, A. N., Ng, J. L., Matanjun, P., Sulaiman, M. R., Tan, T. S., & Ooi, Y. B. H. (2014). Anti-obesity property of the brown seaweed, Sargassum polycystum using an in vivo animal model. Journal of Applied Phycology. 26(2):1043–1048.
De Carvalho, C. A. M., & Thomazini, J. A. (2014). Study of Wistar Rats Heart at Different Stages in the Evolutionary Cycle. International Journal of Morphology. 32(2):614–617.
Erniati E, Malikussaleh U, Rungkat-Zakaria F, Prangdimurti E, & Adawiyah D. 2016. Potensi rumput laut: Kajian komponen bioaktif dan pemanfaatannya sebagai pangan fungsional Seaweed. Aquatic Sciences Journal. 3(1): 12-17.
Jannah N, Yustina Y., Mahedra DN., Sumantri T S., & Husna R A. 2018. Pengaruh Pemberian Ekstrak Umbi Bawang Dayak (Eleutherine Americana Merr.) terhadap Penurunan Kolesterol Pada Tikus Jantan Putih Galur Wistar. Al-Kauniyah: Jurnal Biologi. 11(1): 33–40.
Maharany F, Nurjanah, Suwandi R, Anwar E, H. T. 2017. Kandungan Senyawa Bioaktif Rumput Laut Padina Australis dan Eucheuma Cottonii sebagai Bahan Baku Krim Tabir Surya Bioactive Compounds of Seaweed Padina Australis and Eucheuma Cottonii As Sunscreen Raw Materials. JPHPI. 20(1): 10–17.
Rahma. 2014. Rumput Laut sebagai Bahan Makanan Kaya Serat untuk Penderita Obesitas Pada Remaja. Media Gizi Masyarakat Indonesia. 4(1): 1–8.
Sihombing, M. D. T. S. 2011. Perubahan Nilai Hematologi, Biokimia Darah, Bobot Organ dan Bobot Badan Tikus Putih pada Umur Berbeda. Jurnal Veteriner. 12(1), 58–64.
Suparmi & Sahri A. 2009. Mengenal Potensi Rumput Laut : Kajian Pemanfaatan Sumber Daya Rumput Laut dari Aspek Industri dan Kesehatan. Jurnal Majalah Ilmiah Sultan Agung. 44(118): 95–116.
Wan-Loy C & Siew-Moi P. 2016. Marine Algae as a Potential Source for anti-Obesity Agent. Marine Drugs. 1(14), 1–19.
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