Anti-allergic Activity of 70% Ethanol Extract of Strawberries in Ovalbumin Induced Male Mice
Article Sidebar
-
Allergic, Antianaphylaxis, Fragaria x ananassa (Duchesne ex Weston) Duchesne ex Rozier, Strawberries
Abstract
Anaphylaxis is the most common allergic reaction triggered by allergens such as insect poisons, food, and drugs through skin contact, injection, or inhalation. In vitro previous research showed that strawberries fruit have activity as antioxidant, anticancer, anti-inflammation, and anti-allergic. The research aimed to determine the antianaphylaxis strawberry fruit extract in mice (Balb/C strain) with ovalbumin-induced. Twenty-four Balb/C strain mice were divided into six groups (n=4). Group I and II as a normal and control group. Group III till VI as a treatment group was given cetirizine dose 0.042 mg/20 g BW and strawberry extract doses 0,68; 1,36; and 2,72 mg/20 g BW, respectively. This research showed that 70 % of ethanol extract of strawberries fruit have antiallergic activity in response to active cutaneous anaphylaxis. 70% ethanol extract of strawberries doses 2.72 mg/20 g BW had similar antiallergic activity compare with cetirizine. The conclusion of this study showed that strawberries fruit extract could be developed as an alternative medicine to anti-anaphylaxis or anti-allergic.
Full text article
References
Baratawidjaja, K., Rengganis, I. 2014. Imunologi Dasar. XI. Jakarta (ID): Penerbit Fakultas Kedokteran Universitas Indonesia.
Departemen Kesehatan Republik Indonesia. 2000. Parameter standar umum ekstrak tumbuhan obat. Jakarta (ID): Departemen Kesehatan Republik Indonesia.
Hanani, E. 2014. Analisis Fitokimia. Jakarta (ID): Penerbit Buku Kedokteran EGC.
Harlow E, Lane, M. 1998 Antibodies: A Laboratory Manual. New York (USA): Cold Spring Harbor.
Helmy, M., Munasir, Z. 2007. Pemakaian Cetirizine dan Kortikosteroid pada Penyakit Alergi Anak. Jakarta (ID): Departemen Ilmu Kesehatan Anak.
Huntington JA, PE Stein. 2001. Structure and Properties of ovalbumin. J Chromatogr B Biomed Sci Appl. 756(1-2):189-98.
Iwamoto A, Kazuhiro M, Aiko I, Tamaki K. 2012. Purification and Identification of an IgE Suppressor from Strawberry in an in vitro Immunization System. Cytotechnology. 64(3):309-14
Iwamoto, A. Aiko I, Yuichi I, Koji Y, Hirofumi T & Hiroharu K. 2013. Anti-Allergic Effect of Strawberry Extract. Journal of Functional Foods, 5(4): 1947–1955.
Kardela W, Yufri A, Rozi E. 2017. Uji Efek Anti Anafilaksis Kutan Aktif dari Ekstrak Etanol Bunga Kincung (Etlingera elatior (Jack) R. M. Smith) pada Mencit Putih Jantan. Jurnal Farmasi Higea. 9(1):30-40.
Ninomiya M, Tomohiro I, Suguru I, Miho S, Kenji N, Masaharu Y, Kaneyuki K, Yoshinori N, Mamoru K. 2010. Phenolic Constituents Isolated from Fragaria ananassa Duch Inhibit Antigen-Stimulated Degranulation through Direct Inhibition of Spleen Tyrosine Kinase Activation. Bioorganic & Medical Chemistry. 18(16):5932–5937.
Pebryana AN, Gunawan PW, dan Yul M. 2014. Uji Aktivitas Herba Meniran (Phyllantus Niruri L.) Dan Biji Jinten Hitam (Nigella Sativa L.) terhadap Reaksi Anafilaksis Kutaneus Aktif pada Tikus Galur Wistar Jantan yang Diinduksi Ovalbumin. Jurnal Farmasi Indonesia. 11(2): 181-187.
Selvia E, Aulia AH, Endang SW. 2014. Uji Efek Antimikroba Ekstrak Ethanol Stroberi (Fragaria vesca L.) terhadap Staphylococcus epidermidis. Majalah Kesehatan Fakultas Kedokteran Universitas Brawijaya. 1(2): 81-85.
Susanto, J. 2010. Efek Infusa Kulit Batang Pulasari (Alixia reinwardtii Bl.) Terhadap Reaksi Anafilaksis Kutan Aktif yang Diinduksi Ovalbumin pada Tikus Wistar Jantan. [skripsi]. Yogyakarta (ID): Fakultas Farmasi Universitas Sanata Dharma Yogyakarta.
Trimayanti, Y., Gunawan, P. W., Mariyah, Y. 2015. Uji Aktivitas Ekstrak Etanol Herba Sambiloto (Andrographis paniculata Nees) dan Biji Jinten Hitam (Nigella sativa L.) terhadap Reaksi Anafilaksis Kutan Aktif pada Tikus Putih Wistar Jantan yang Diinduksi Ovalbumin’ Jurnal Farmasi Indonesia. 1112(1):70-78.
Widyastuti W, Ariya EK, Nurlaili N, Fitriani S. 2016. Aktivitas Antioksidan dan Tabir Surya Ekstrak Etanol Daun Stroberi (Fragaria x ananassa A.N. Duchesne)., Jurnal Sains Farmasi & Klinis. 3(1):19.
Authors
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Copyright @2017. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted non-commercial used, distribution and reproduction in any medium