Therapeutic Effects of Morus alba Leaf Extract on Fasting Blood Glucose and Pancreatic β-Cell Restoration in HFD–STZ-Induced Diabetic Rats

Mirnawati  Salampe; Dewa Ayu Diah Widiasri; Nurzadrina Wahyuddin; Rezki Rahayu  Agus; Imrawati Imrawati; Akbar Awaluddin; Wahyuni Wahyuni; Akbar Awaluddin

doi:10.29244/jji.v11i2.452

Mirnawati Salampe⁽¹⁾, Dewa Ayu Diah Widiasri⁽²⁾, Nurzadrina Wahyuddin⁽³⁾, Rezki Rahayu Agus⁽⁴⁾, Imrawati Imrawati⁽⁵⁾, Akbar Awaluddin⁽⁶⁾, Wahyuni Wahyuni⁽⁷⁾, Akbar Awaluddin⁽⁸⁾

(1) Department of Pharmacology and Clinical Pharmacy, Faculty of Health Sciences, Universitas Almarisah Madani, Makassar, 90245,

(2) Department of Pharmacology and Clinical Pharmacy, Faculty of Health Sciences, Universitas Almarisah Madani, Makassar, 90245,

(3) Department of Pharmacology and Clinical Pharmacy, Faculty of Health Sciences, Universitas Almarisah Madani, Makassar, 90245,

(4) Department of Pharmacology and Clinical Pharmacy, Faculty of Health Sciences, Universitas Almarisah Madani, Makassar, 90245,

(5) Department of Pharmaceutical Chemistry, Faculty of Health Sciences, Universitas Almarisah Madani, Makassar, 90245,

(6) Department of Pharmacology and Clinical Pharmacy, Faculty of Health Sciences, Universitas Almarisah Madani, Makassar, 90245,

(7) Disease Investigation Centre of Maros, Maros, Sulawesi Selatan, 90514,

(8) Department of Pharmacology and Clinical Pharmacy, Faculty of Health Sciences, Universitas Almarisah Madani, Makassar, 90245

https://doi.org/10.29244/jji.v11i2.452

Therapeutic Effects of Morus alba Leaf Extract on Fasting Blood Glucose and Pancreatic β-Cell Restoration in HFD–STZ-Induced Diabetic Rats

Issue
Vol. 11 No. 2 (2026): Jurnal Jamu Indonesia (In Progress)

Submitted
November 13, 2025

Accepted
March 3, 2026

Published
March 20, 2026

Keywords:

Diabetes mellitus, Metabolic syndrome, Morus alba, Pancreatic β-cells

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Abstract

Type 2 diabetes mellitus (T2DM) is characterized by chronic hyperglycemia caused by insulin resistance and pancreatic β-cell dysfunction. Morus alba leaves contain bioactive compounds with potential antidiabetic activity. This study evaluated the hypoglycemic and β-cell protective effects of ethanolic M. alba leaf extract (EMA) in diabetic rats. The extract was obtained through maceration, yielding 12.14%. Wistar rats were divided into normal control, negative control, positive control, EMA100 (100 mg/kg BW), and EMA200 (200 mg/kg BW). Diabetes was induced using a high-fat diet, 2% sucrose solution, and low-dose streptozotocin. Fasting blood glucose (FBG) and pancreatic histopathology were analyzed. EMA significantly reduced FBG and improved pancreatic β-cell morphology, particularly at 200 mg/kg BW. These findings suggest that EMA has potential as a therapeutic candidate for T2DM by improving glycemic control and preserving pancreatic β-cell integrity.

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