Formulation and Evaluation Stick Moisturizing Combination of Aloe Vera Extract (Aloe barbadensis mill) and Chamomile (Matricaria recutita)
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Antioxidant, Aloe Vera, Chamomile, Factorial design, Moisturizer Stick
Abstract
Aloe vera (Aloe barbadensis mill) and chamomile (Matricaria recutita) contain active compounds in the form of aloin and apigenin, which function as moisturizers with soothing and antioxidant effects that can neutralize free radicals that cause oxidative stress on the skin. This study aims to determine the optimal formula for a moisturizing stick that combines Aloe vera and chamomile extracts, based on physical properties, effectiveness as a moisturizer, and antioxidant activity. The dry extract was obtained by percolation with 96% ethanol and dried using a spray dryer. The dry extract will be standardized for specific and non-specific tests. The optimum moisturizing stick formula was obtained using the factorial design method. The factors used were aloe vera extract with a concentration of (-1) 10% and a concentration of (+1) 20%, as well as chamomile extract with a concentration of (-1) 5% and a concentration of (+1) 15%. Determination of the optimum formula was carried out using a factorial design method using the following responses: hardness, spreadability, moisture [AUC], and antioxidant activity (IC50). The moisturizing stick formulation uses a hot melt extrusion method. The data from the parametric experiments between batches and formulas will be analyzed using the One-Way Anova (Yate's Treatment). The results showed that increasing aloe vera extract increased the spreadability and moisture, while increasing chamomile extract increased the antioxidant activity. The interaction between the extracts had a significant effect on all parameters. The optimum formula was obtained at a concentration of 18.711% aloe vera and 8.167% chamomile, which met the quality and effectiveness criteria.
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References
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