Jurnal Jamu Indonesia
type: channel
description: Journal Title : Jurnal Jamu Indonesia (JJI) or Indonesian Journal of Jamu Abbreviation : JJI Scope : Herbal Medicine Type of manuscript : Research papers, short communications and review articles Frequency : Starting in 2026 JJI is published six times a year (February, April, June, August, October, and December) DOI : 10.29244/v10i1 Print ISSN : 2407-7178 Online ISSN : 2407-7763 Publisher : TropBRC IPB University Language : Starting from Volume 11 in 2026, all manuscripts must be written in English. Authors may submit in Bahasa Indonesian; however, if accepted, the manuscript will be subject to a translation fee handled by the JJI language editorial team. Indexing : Sinta 2, Google Scholar Open Access Policy : CC BY-NC-SA 4.0 Preservation Archiving : PKP PN Jurnal Jamu Indonesia (JJI) or Indonesian Journal of Jamu is dedicated to the exchange of information and widespread scientific understanding regarding the development of the world of herbal medicine through the publication of scientific papers. The themes of scientific papers within the scope of JJI include the theme of herbal medicine research from upstream to downstream which is not limited to ethnobotanical research and local knowledge, exploration, conservation, domestication of biological resources related to herbal medicine, variety breeding, development of Good Agricultural and Collection Practices (GACP) for herbal medicine raw materials, development of standards for raw materials and herbal medicine products, development of herbal medicine products, identification of active compounds and their synthesis, working mechanisms for the bioactivity of herbal medicine formulas, social and economic aspects related to the development of herbal medicine.
publisher: Tropical Biopharmaca Research Center, IPB University
language: en
publication name: Jurnal Jamu Indonesia
issn: 2407-7178
copyright: This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Copyright @2017. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted non-commercial used, distribution and reproduction in any medium
items: Table of Contents
items: Molecular Docking and ADMET Analysis of Bioactive Compounds from Vitex trifolia as Potential COX-2 Anti-Inflammatory Agents
items: Anticholesterolemic Evaluation of Physalis angulata L. Ethanolic Extract Using In Vitro, GC-MS, and Docking Approaches
items: Production and Phytochemical Variation of Kaempferia rotunda Rhizomes in Relation to Soil Nutrient Conditions on Madura Island
items: Formulation and Antibacterial Evaluation of Ethanolic Garlic Peel Emulgel Against Staphylococcus aureus and Propionibacterium acnes
items: In Vitro and In Silico Evaluation of Pancreatic Lipase Inhibition by Avicennia marina and Bruguiera gymnorrhiza Fruit Flour Extracts
items: Formulation and Evaluation Stick Moisturizing Combination of Aloe Vera Extract (Aloe barbadensis mill) and Chamomile (Matricaria recutita)
items: Formulation of Antioxidant Cream from Mung Bean (Vigna radiata L.) Seed Coat Extract
items: LC-MS/MS Profiling and Anti-inflammatory Activity of Red Onion (Allium cepa L. var. Bima Brebes) Extract-Based Liniment in Mus musculus
items: Phytochemical Profile, Antioxidant Activity, and Hematological and Liver–Kidney Serum Markers of Lampung Green Robusta Coffee Extract in Lead-Induced Mice
items: Development and Evaluation of Topical Gel Containing Rosa spp. Extract for Anti-Acne and Anti-Aging Properties
items: Therapeutic Effects of Morus alba Leaf Extract on Fasting Blood Glucose and Pancreatic β-Cell Restoration in HFD–STZ-Induced Diabetic Rats
items: Gastroprotective Effect of the Aqueous Fraction of Tamarindus indica L. Leaves Against Aspirin-Induced Gastric Injury in Mice
items: Jamoetics: A Web-Based Information System for Indonesian Herbal Database
items: Optimization of Black Orchid (Coelogyne pandurata Lindl.) Extraction Using Simplex-Centroid Design for Total Phenolics, Flavonoids, and Antioxidants
items: Comparative Analysis of Total Flavonoid Content and Antioxidant Activity in Medicinal Plant Leaf Extracts Using Ethanol and Citric Acid
items: Molecular Docking of Active Compound of Okra (Abelmoschus esculentus L.) on α-Glucosidase as Antidibetic Mellitus Drug Candidate
items: Antibacterial Activity of Esterified Trigona laeviceps Hive Waste Extract against Skin-Associated Bacteria
items: Evaluation of the Antibacterial Activity of Muntingia calabura L. Leaf Extract in Anti-Acne Serum and Gel Moisturizer Formulations
items: Cytotoxic Effect of Brazilin on DU145 Prostate Cancer Cells Using the WST-8 Assay
items: Optimizing Ultrasonic Extraction of Enhalus acoroides to Enhance Physicochemical Traits and Antioxidant Activity
items: Specific and Non-Specific Safety Testing of Red Gedi Leaf Ethanol Extract (Abelmoschus manihot L. Medik)
items: Phytochemical Screening and Antibacterial Activity of Jackfruit Seed Extract (Artocarpus heterophyllus Lamk.) Against Salmonella typhi In Vitro
items: Metabolite Profiling and Bioactivity Assessment of Antioxidant and Antibacterial Properties in Bulb Fractions of Eleutherine bulbosa (Mill.) Urb
items: In Silico Evaluation of Flavonoids from Imperata cylindrica as Potential Antidiabetic Agents
items: Optimizing Curcumin SNEDDS via D-Optimal Design and Evaluating Wound Healing Efficacy in Wistar Rats
items: Ethnopharmacological Study of Medicinal Plants Used by the Dayak Tunjung Benuaq Tribe in East Kalimantan, Indonesia
items: In Silico Exploration of Orthosiphon stamineus Compounds as Potential Angiotensin Receptor Blockers for Hypertension Therapy

Table of Contents
type: item
subject: Full Issue
  topic: section
creator: Jurnal Jamu Indonesia
rights: Copyright (c) 2026 Jurnal Jamu Indonesia
date: 2026-03-20
publication date: 2026-03-20
doi: 10.29244/jji.v11i2.502

Molecular Docking and ADMET Analysis of Bioactive Compounds from Vitex trifolia as Potential COX-2 Anti-Inflammatory Agents
type: item
description: Legundi (Vitex trifolia) has been reported to exhibit anti-inflammatory activity; however, the specific bioactive compounds responsible for this effect remain unclear. This study aimed to evaluate the anti-inflammatory potential of bioactive compounds from V. trifolia against cyclooxygenase-2 (COX-2; PDB ID: 5KIR) using an in silico molecular docking approach, along with the analysis of their pharmacokinetic and toxicity profiles. The results showed that persicogenin exhibited the lowest binding affinity of −9.2 kcal/mol and formed hydrogen bonds with key amino acid residues, namely THR 212, HIS 207, and TYR 385. ADMET prediction results indicated that persicogenin met the drug-likeness criteria for an oral drug candidate, demonstrated good intestinal absorption (HIA: 92.29%), high membrane permeability (Caco-2 permeability > 0.9), low volume of distribution (VDss < 0.45), inhibitory activity against CYP2C19 and CYP3A4, and no hepatotoxic potential. These findings suggest that persicogenin may serve as an anti-inflammatory agent.
subject: Articles
  topic: section
subject: Anti-inflammatory
  topic: keywords
subject: COX-2
  topic: keywords
subject: In silico
  topic: keywords
subject: Molecular docking
  topic: keywords
subject: Vitex trifolia
  topic: keywords
creator: Hanif Hibatulloh
creator: Zulpakor Oktoba
creator: Atri Sri Ulandari
creator: Muhammad Iqbal
creator: Recky Patala
rights: Copyright (c) 2026 Jurnal Jamu Indonesia
date: 2026-03-20
publication date: 2026-03-20
starting page: 104
ending page: 110
doi: 10.29244/jji.v11i2.460

Anticholesterolemic Evaluation of Physalis angulata L. Ethanolic Extract Using In Vitro, GC-MS, and Docking Approaches
type: item
description: Physalis angulata L. is traditionally used as a medicinal plant and contains various pharmacologically active metabolites. This study evaluated the anticholesterolemic potential of P. angulata ethanolic extract using in vitro assays, gas chromatography–mass spectrometry (GC-MS), and molecular docking. The extract obtained by remaceration contained flavonoids, phenolics, tannins, saponins, and steroids/triterpenoids. Thin-layer chromatography indicated the presence of terpenoids, flavonoids, essential oils, and saponins. Quantitative analysis showed flavonoid, phenolic, tannin, and sterol contents of 34.86 ± 1.11 mg RE/g, 5.14 ± 0.15 mg GAE/g, 0.99 ± 0.01%, and 0.072 ± 0.0004 mg CE/g, respectively. Antioxidant IC₅₀ values were 209.55 ± 9.10 ppm for DPPH and 220.18 ± 4.23 ppm for FRAP. The Liebermann–Burchard assay showed cholesterol inhibition with an IC₅₀ of 96.11 ppm. GC-MS tentatively identified several compounds, while molecular docking suggested favora
subject: Articles
  topic: section
subject: Cholesterol inhibition
  topic: keywords
subject: GC-MS
  topic: keywords
subject: Molecular docking
  topic: keywords
subject: Physalis angulata
  topic: keywords
subject: Phytochemical screening
  topic: keywords
creator: Eka Susanti Hanhadyanaputri
creator: Muhammad Rahardhian
creator: Eka Septiana
rights: Copyright (c) 2026 Jurnal Jamu Indonesia
date: 2026-05-26
publication date: 2026-05-26
doi: 10.29244/10.29244/jji.v11i3.428

Table of Contents
type: item
description: Table of Contents
subject: Full Issue
  topic: section
creator: Jurnal Jamu Indonesia
rights: Copyright (c) 2026 Jurnal Jamu Indonesia
date: 2026-02-06
publication date: 2026-02-06
doi: 10.29244/jji.v11i1.491

Production and Phytochemical Variation of Kaempferia rotunda Rhizomes in Relation to Soil Nutrient Conditions on Madura Island
type: item
description: Kaempferia rotunda L. is a traditional medicinal plant in Madura. This study aimed to evaluate the production and phytochemical variation of K. rotunda rhizomes from Madura Island and to determine the soil chemical factors associated with these traits. Plant materials and soil samples were collected from ex situ cultivation areas in Bangkalan, Sampang, Pamekasan, and Sumenep. Rhizome production, simplicia yield, extract yield, total phenolics, total tannins, total steroids, and soil nutrient contents were analyzed. The results showed substantial variation among accessions in both production and phytochemical contents. Primary rhizome weight was positively correlated with the number of secondary rhizomes, whereas secondary rhizome simplicia yield was positively correlated with total rhizome simplicia yield. Soil nutrients showed low-to-moderate correlations with production traits but strong correlations with phytochemical contents. Suitable accession selection combined with balanced macro- and micronutrient availability may improve rhizome yield and quality.
subject: Articles
  topic: section
subject: Accession
  topic: keywords
subject: Extract Yield
  topic: keywords
subject: Micronutrient
  topic: keywords
subject: Rhizome
  topic: keywords
subject: Simplicia Yield
  topic: keywords
creator: Diana Nurus Sholehah
creator: Risqiyah Risqiyah
creator: Suci Aulia Putri
creator: Choirul Umam
creator: Fadlilaturrahmah Fadlilaturrahmah
creator: Sinar Suryawati
rights: Copyright (c) 2026 Jurnal Jamu Indonesia
date: 2026-03-25
publication date: 2026-03-25
starting page: 135
ending page: 143
doi: 10.29244/jji.v11i2.459

Formulation and Antibacterial Evaluation of Ethanolic Garlic Peel Emulgel Against Staphylococcus aureus and Propionibacterium acnes
type: item
description: Garlic peel (Allium sativum L.) is a household waste that contains bioactive compounds with potential antibacterial activity. This study aimed to formulate an emulgel containing ethanolic garlic peel extract and evaluate its physical characteristics and antibacterial activity against Staphylococcus aureus and Propionibacterium acnes. The emulgel was evaluated for organoleptic properties, homogeneity, pH, and viscosity. Antibacterial activity was tested using the agar diffusion method. The formulation showed acceptable physical characteristics for topical use. The emulgel inhibited the growth of both bacteria, with inhibition zones of 12.16 mm against S. aureus and 11.02 mm against P. acnes. The antibacterial activity may be related to the presence of flavonoids, saponins, phenolic compounds, and allicin in garlic peel extract. These results suggest that garlic peel extract can be formulated into an emulgel with potential antibacterial activity.
subject: Communication
  topic: section
subject: emulgel
  topic: keywords
subject: garlic peel extract
  topic: keywords
subject: antibacterial activity
  topic: keywords
subject: Staphylococcus aureus
  topic: keywords
subject: Propionibacterium acnes
  topic: keywords
creator: Michrun Nisa
creator: Sukriani Kursia
creator: Rahmah Mustarin
creator: Zulfiah Zulfiah
creator: Wiranda Karmianti
rights: Copyright (c) 2026 Jurnal Jamu Indonesia
date: 2026-03-20
publication date: 2026-03-20
starting page: 99
ending page: 103
doi: 10.29244/jji.v11i2.451

In Vitro and In Silico Evaluation of Pancreatic Lipase Inhibition by Avicennia marina and Bruguiera gymnorrhiza Fruit Flour Extracts
type: item
description: Indonesia is rich in mangrove species, including Avicennia marina (brayo) and Bruguiera gymnorrhiza (lindur), whose fruits contain bioactive metabolites with potential anti-obesity activity. This study evaluated pancreatic lipase inhibition by brayo and lindur fruit flour extracts (raw and boiled) using in vitro and in silico approaches. Extracts were prepared by remaceration with 70% ethanol. Lipase inhibition was measured using a multimode microplate reader, while metabolites were identified by LC-HRMS and evaluated by molecular docking. Raw brayo showed the highest inhibition (84.29 ± 4.24%), followed by boiled brayo (83.01 ± 4.59%), raw lindur (75.24 ± 3.02%), and boiled lindur (73.88 ± 4.00%). Docking indicated strong binding of luteolin (−8.23 kcal/mol), 9-oxo-10(E),12(E)-octadecadienoic acid (−6.75 kcal/mol), and methyl eleostearate (−6.59 kcal/mol) to pancreatic lipase. These findings support mangrove fruit flour as a natural source of lipase inhibitors for obesity management.
subject: Articles
  topic: section
subject: pancreatic lipase
  topic: keywords
subject: mangrove fruit extract
  topic: keywords
subject: anti-obesity
  topic: keywords
subject: in vitro
  topic: keywords
subject: in silico
  topic: keywords
creator: Afra Chairunnisa
creator: Muhammad Ryan Radix Rahardian
creator: Ratih Pangestuti
creator: Yuvianti Dwi Franyoto
creator: Lia Kusmita
rights: Copyright (c) 2026 Jurnal Jamu Indonesia
date: 2026-03-20
publication date: 2026-03-20
starting page: 89
ending page: 98
doi: 10.29244/jji.v11i2.483

Formulation and Evaluation Stick Moisturizing Combination of Aloe Vera Extract (Aloe barbadensis mill) and Chamomile (Matricaria recutita)
type: item
description: Aloe vera (Aloe barbadensis mill) and chamomile (Matricaria recutita) contain active compounds in the form of aloin and apigenin, which function as moisturizers with soothing and antioxidant effects that can neutralize free radicals that cause oxidative stress on the skin. This study aims to determine the optimal formula for a moisturizing stick that combines Aloe vera and chamomile extracts, based on physical properties, effectiveness as a moisturizer, and antioxidant activity. The dry extract was obtained by percolation with 96% ethanol and dried using a spray dryer. The dry extract will be standardized for specific and non-specific tests. The optimum moisturizing stick formula was obtained using the factorial design method. The factors used were aloe vera extract with a concentration of (-1) 10% and a concentration of (+1) 20%, as well as chamomile extract with a concentration of (-1) 5% and a concentration of (+1) 15%. Determination of the optimum formula was carried out using a factorial design method using the following responses: hardness, spreadability, moisture [AUC], and antioxidant activity (IC50). The moisturizing stick formulation uses a hot melt extrusion method. The data from the parametric experiments between batches and formulas will be analyzed using the One-Way Anova (Yate's Treatment). The results showed that increasing aloe vera extract increased the spreadability and moisture, while increasing chamomile extract increased the antioxidant activity. The interaction between the extracts had a significant effect on all parameters. The optimum formula was obtained at a concentration of 18.711% aloe vera and 8.167% chamomile, which met the quality and effectiveness criteria.
subject: Articles
  topic: section
subject: Antioxidant
  topic: keywords
subject: Aloe Vera
  topic: keywords
subject: Chamomile
  topic: keywords
subject: Factorial design
  topic: keywords
subject: Moisturizer Stick
  topic: keywords
creator: Meilani Kezia Tiandreas
creator: Farida Lanawati Darsono
creator: Shinta Marito Simbolon
rights: Copyright (c) 2026 Jurnal Jamu Indonesia
date: 2026-03-20
publication date: 2026-03-20
starting page: 79
ending page: 88
doi: 10.29244/jji.v11i2.434

Formulation of Antioxidant Cream from Mung Bean (Vigna radiata L.) Seed Coat Extract
type: item
description: The skin is the body’s primary barrier against free radicals, which can induce oxidative stress and premature ageing. Antioxidants neutralize these radicals. This study aims to formulate and evaluate a cream containing ethanol extract of mung bean (Vigna radiata L.) seed coat. Four formulations were prepared with extract concentrations of 10%, 15%, 20%, and 25%. Physical evaluations included organoleptic tests, homogeneity, pH, viscosity, cream type, spreadability, and adhesiveness. Antioxidant activity was measured using the DPPH method. All formulations met physical standards, and formula F4 (25%) showed the highest antioxidant activity with an IC₅₀ value of 79.49 ppm. These findings indicate the potential of mung bean seed coat extract as an active antioxidant agent in topical preparations.
subject: Articles
  topic: section
subject: Antioxidant activity
  topic: keywords
subject: Cream
  topic: keywords
subject: DPPH
  topic: keywords
subject: Mung bean seed coat extract
  topic: keywords
subject: Vigna radiata
  topic: keywords
creator: Hermanus Ehe Hurit
creator: Linda Handayani
creator: Reinaldo Pradana
creator: Dara Andini Putri
rights: Copyright (c) 2026 Jurnal Jamu Indonesia
date: 2026-02-06
publication date: 2026-02-06
starting page: 72
ending page: 78
doi: 10.29244/jji.v11i1.475

LC-MS/MS Profiling and Anti-inflammatory Activity of Red Onion (Allium cepa L. var. Bima Brebes) Extract-Based Liniment in Mus musculus
type: item
description: Allium cepa L. (Bima Brebes variety) is a prolific source of quercetin-type flavonols and organosulfur compounds, recognized for their potent anti-inflammatory and antioxidant activities. Topical herbal liniments offer a practical approach to manage localized inflammation while minimizing systemic exposure. This study aimed to evaluate the anti-inflammatory activity of a topical liniment formulated with a 70% ethanolic extract of A. cepa. LC–MS/MS (UHPLC Vanquish Tandem Q) had identified ten secondary metabolites putatively linked to anti-inflammatory effects. Anti-inflammatory efficacy was evaluated in vivo using a carrageenan-induced paw oedema model in male mice. Oedema inhibition was recorded at 18% in the negative control, 47% in the positive control, and 38%, 42%, and 44% for the 2 g, 3 g, and 5 g formulations, respectively. One-way ANOVA revealed significant differences among groups (p = 0.001). These findings suggested that A. cepa-based liniment formulations may serve as promising candidates as natural topical anti-inflammatory agents.
subject: Articles
  topic: section
subject: Allium cepa L.
  topic: keywords
subject: Anti-inflammatory
  topic: keywords
subject: Liniment
  topic: keywords
subject: Mus musculus
  topic: keywords
creator: Melisa Saragih
creator: Siwardin Harefa
creator: Kezia Rahel
creator: Ratu Sukma Ruhi
creator: Ekarin Lativa Rahmaningtyas
creator: Laurencia Chrisiana Eliasari
creator: Riskianto Riskianto
rights: Copyright (c) 2026 Jurnal Jamu Indonesia
date: 2026-02-06
publication date: 2026-02-06
starting page: 39
ending page: 47
doi: 10.29244/jji.v11i1.422

Phytochemical Profile, Antioxidant Activity, and Hematological and Liver–Kidney Serum Markers of Lampung Green Robusta Coffee Extract in Lead-Induced Mice
type: item
description: Lampung Province is one of Indonesia’s major robusta coffee–producing regions, and green coffee beans contain bioactive compounds with potential biological benefits. This study analyzed the phytochemical composition and antioxidant activity of ethanolic extract of Lampung green robusta coffee beans and evaluated its effects on hematological parameters and liver–kidney serum markers in lead acetate–induced mice. Phytochemical screening revealed alkaloids, flavonoids, phenolics, saponins, tannins, and terpenoids. Quantitative analysis showed total phenolics of 122.76 mg GAE/g extract, flavonoids of 12.23 mg QE/g extract, tannins of 208.86 mg TAE/g extract, and saponins of 1.32%. The extract exhibited very strong antioxidant activity (IC₅₀ = 21.99 ppm). Lead acetate exposure (20 mg/kg BW for 14 days) decreased erythrocyte counts and increased leukocyte and urea levels. Administration of the extract (400 mg/kg BW) improved erythrocyte counts, modulated leukocyte levels, and reduced urea concentrations.
subject: Articles
  topic: section
subject: antioxidant activity
  topic: keywords
subject: hematological parameters
  topic: keywords
subject: phytochemicals
  topic: keywords
subject: robusta coffee
  topic: keywords
creator: Iffa Afiqa Khairani
creator: Jeni Putri Ananta
creator: Kiki Firmansyah
creator: Hida Arliani Nur Anisa
creator: Elisa Nurma Riana
creator: Jeane Siswitasari Mulyana
creator: Rizka Fatriani
rights: Copyright (c) 2026 Jurnal Jamu Indonesia
date: 2026-03-20
publication date: 2026-03-20
starting page: 152
ending page: 163
doi: 10.29244/jji.v11i2.472

Development and Evaluation of Topical Gel Containing Rosa spp. Extract for Anti-Acne and Anti-Aging Properties
type: item
description: The present study aimed to develop and evaluate a topical gel containing ethanolic red rose flower extract as a potential natural anti-acne and anti-aging preparation. The extract was screened for phytochemicals, and the gel was formulated with varying concentrations of Carbopol 940 (0.25-1.25%). The gels were characterized for their organoleptic properties, pH, viscosity, spreadability, and in vitro antibacterial activity against Cutibacterium acnes. Phytochemical screening revealed the presence of alkaloids, flavonoids, quinones, tannins, saponins, triterpenoids, and anthocyanins in the extract. Organoleptic evaluation showed that Formulas 2 (0.5% Carbopol) and 3 (0.75% Carbopol) had the most suitable characteristics for a cosmetic gel, with moderate viscosity, non-greasiness, rapid absorption, and user comfort. Viscosity testing confirmed pseudoplastic flow behavior, with Formulas 2 and 3 exhibiting an optimal balance between physical stability and ease of application. Spreadability and adhesiveness tests further supported the suitability of these formulas. The pH of all formulas ranged from 7.02 to 7.08, requiring further optimization to match the skin's physiological pH. Antibacterial testing revealed that all gel formulas containing 1% extract showed strong inhibition against C. acnes (inhibition zones of 15.0 ± 1.2–1.3 mm), attributed to the presence of flavonoids, tannins, and other bioactive compounds. The results suggest that the red rose flower extract gel, particularly Formulas 2 and 3, has promising potential as a natural anti-acne and anti-aging preparation, offering a balance of physical stability, user comfort, and antibacterial activity.
subject: Articles
  topic: section
subject: Antibacterial activity
  topic: keywords
subject: Cutibacterium acnes
  topic: keywords
subject: Physicochemical evaluation
  topic: keywords
subject: Rosa spp.
  topic: keywords
subject: Topical gel
  topic: keywords
creator: Diki Zaelani
creator: Abdul Mulki Irfani
creator: Merylance Stefany Sanggo
creator: Jajang Japar Sodik
creator: Reza Pratama
rights: Copyright (c) 2026 Jurnal Jamu Indonesia
date: 2026-03-20
publication date: 2026-03-20
starting page: 128
ending page: 134
doi: 10.29244/jji.v11i2.470

Therapeutic Effects of Morus alba Leaf Extract on Fasting Blood Glucose and Pancreatic β-Cell Restoration in HFD–STZ-Induced Diabetic Rats
type: item
description: Type 2 diabetes mellitus (T2DM) is characterized by chronic hyperglycemia caused by insulin resistance and pancreatic β-cell dysfunction. Morus alba leaves contain bioactive compounds with potential antidiabetic activity. This study evaluated the hypoglycemic and β-cell protective effects of ethanolic M. alba leaf extract (EMA) in diabetic rats. The extract was obtained through maceration, yielding 12.14%. Wistar rats were divided into normal control, negative control, positive control, EMA100 (100 mg/kg BW), and EMA200 (200 mg/kg BW). Diabetes was induced using a high-fat diet, 2% sucrose solution, and low-dose streptozotocin. Fasting blood glucose (FBG) and pancreatic histopathology were analyzed. EMA significantly reduced FBG and improved pancreatic β-cell morphology, particularly at 200 mg/kg BW. These findings suggest that EMA has potential as a therapeutic candidate for T2DM by improving glycemic control and preserving pancreatic β-cell integrity.
subject: Articles
  topic: section
subject: Diabetes mellitus
  topic: keywords
subject: Metabolic syndrome
  topic: keywords
subject: Morus alba
  topic: keywords
subject: Pancreatic β-cells
  topic: keywords
creator: Mirnawati Salampe
creator: Dewa Ayu Diah Widiasri
creator: Nurzadrina Wahyuddin
creator: Rezki Rahayu Agus
creator: Imrawati Imrawati
creator: Akbar Awaluddin
creator: Wahyuni Wahyuni
rights: Copyright (c) 2026 Jurnal Jamu Indonesia
date: 2026-03-20
publication date: 2026-03-20
starting page: 111
ending page: 118
doi: 10.29244/jji.v11i2.452

Gastroprotective Effect of the Aqueous Fraction of Tamarindus indica L. Leaves Against Aspirin-Induced Gastric Injury in Mice
type: item
description: Tamarindus indica L. leaves contain bioactive compounds, particularly tannins and saponins, which may contribute to gastric mucosal protection. This study aimed to evaluate the gastroprotective effect of the aqueous fraction of T. indica leaves in aspirin-induced gastric injury in mice. Twelve mice were randomly divided into four groups (n = 3): normal control, negative control, and two treatment groups receiving the aqueous fraction at doses of 6 mg/30 g and 12 mg/30 g body weight prior to aspirin induction. Gastroprotective activity was assessed through macroscopic observation and histopathological examination of gastric tissues. Aspirin administration caused gastric mucosal injury characterized by erosion, ulceration, and hemorrhage. Treatment with the aqueous fraction reduced gastric damage and improved epithelial integrity. The dose of 12 mg/30 g body weight showed the most pronounced protective effect. These findings suggest that the aqueous fraction of T. indica leaves has potential gastroprotective activity.
subject: Articles
  topic: section
subject: Tamarindus indica L
  topic: keywords
subject: Aqueous fraction
  topic: keywords
subject: Gastroprotective
  topic: keywords
subject: Aspirin
  topic: keywords
subject: Gastric mucosa
  topic: keywords
creator: Sitti Rahimah
creator: Maulita Indrisari
creator: Devia Novelia Patabang
rights: Copyright (c) 2026 Jurnal Jamu Indonesia
date: 2026-04-01
publication date: 2026-04-01
starting page: 144
ending page: 151
doi: 10.29244/jji.v11i2.462

Jamoetics: A Web-Based Information System for Indonesian Herbal Database
type: item
description: This study aimed to develop a web-based information system for herbal plants in Indonesia. This research began with data collection, prototype making, and evaluation. This research was conducted by combining a literature review, simulation, and survey. Literature reviews were used to gather scientific information about various herbal medicines. The website was hosted on a platform-as-a-service cloud service. The web is accessible at https://www.jamoetics.com. All data from the questionnaire were analyzed using descriptive statistics. The data on this website were obtained from various sources grouped into monographs, public databases, and scientific journals. The “Jamoetics” system evaluation survey showed that 98.25% of respondents felt confident and interested in using the “Jamoetics” website because of its ease of access to information, completeness of information, and user-friendly interface. Jamoetics, a web-based information system, can help communities easily access information about herbal plants in Indonesia.
subject: Articles
  topic: section
subject: Biodiversity
  topic: keywords
subject: education
  topic: keywords
subject: herbal plants
  topic: keywords
subject: information system
  topic: keywords
subject: natural products database
  topic: keywords
creator: Oeke Yunita
creator: Jimmy Jimmy
creator: Jasti Ohanna
creator: Theophil Henry Soegianto
creator: Erlin Theterissa
rights: Copyright (c) 2026 Jurnal Jamu Indonesia
date: 2026-03-29
publication date: 2026-03-29
starting page: 119
ending page: 127
doi: 10.29244/jji.v11i2.425

Optimization of Black Orchid (Coelogyne pandurata Lindl.) Extraction Using Simplex-Centroid Design for Total Phenolics, Flavonoids, and Antioxidants
type: item
description: Coelogyne pandurata Lindl., a black orchid endemic to Kalimantan, contains valuable antioxidant compounds. This study optimized its extraction using a Simplex-Centroid Mixture Design with ethanol, methanol, and acetic acid as solvents. Responses evaluated were total phenolic content (TPC), total flavonoid content (TFC), and antioxidant capacity (DPPH). The highest TPC was obtained with 100% ethanol (2.52 mg GAE/g), TFC with equal parts of all solvents (6.41 mg QE/g), and antioxidant activity with 100% methanol (10.33 µmol TE/g). Ethanol yielded the optimal extraction condition, with verification values of 2.27 mg GAE/g (TPC), 3.42 mg QE/g (TFC), and 10.22 µmol TE/g (DPPH), and a desirability of 0.739. Although regression models were not statistically significant (p > 0.05), the results provide preliminary insights into solvent efficiency for extracting bioactive compounds. Further studies with expanded experimental designs and validation are required to enhance model accuracy and extraction reliability.
subject: Articles
  topic: section
subject: Antioxidant compounds
  topic: keywords
subject: Black orchid
  topic: keywords
subject: Extraction design
  topic: keywords
creator: Pebra Heriansyah
creator: Novian Liwanda
creator: Waras Nurcholis
rights: Copyright (c) 2026 Jurnal Jamu Indonesia
date: 2026-02-06
publication date: 2026-02-06
starting page: 66
ending page: 71
doi: 10.29244/jji.v11i1.457

Comparative Analysis of Total Flavonoid Content and Antioxidant Activity in Medicinal Plant Leaf Extracts Using Ethanol and Citric Acid
type: item
description: Flavonoids are bioactive compounds with antioxidant activity, and their extraction efficiency is strongly influenced by solvent selection. This study compared total flavonoid content and antioxidant activity of leaf extracts from Persea americana, Annona muricata, Piper betle, and Pandanus amaryllifolius obtained using ethanol and citric acid. Total flavonoid content was determined using the AlCl₃ spectrophotometric method with quercetin as the reference standard, while antioxidant activity was evaluated by the DPPH assay. Ethanol generally yielded higher flavonoid levels, with the highest content observed in P. americana leaves (3.87 mg QE/g), whereas citric acid extracts exhibited stronger antioxidant activity, reaching 94.21% DPPH inhibition in P. betle leaves. No significant correlation was observed between total flavonoid content and antioxidant activity. Overall, these results indicated that solvent selection critically determines extraction outcomes, and citric acid represents a viable green alternative for antioxidant-oriented applications.
subject: Articles
  topic: section
subject: Antioxidants
  topic: keywords
subject: Citric Acid
  topic: keywords
subject: Ethanol
  topic: keywords
subject: Flavonoid
  topic: keywords
subject: Green Solvent
  topic: keywords
creator: Syaikhul Aziz
creator: Isna Mulyani
creator: Syaadatun Nadiah
rights: Copyright (c) 2026 Jurnal Jamu Indonesia
date: 2026-02-06
publication date: 2026-02-06
starting page: 52
ending page: 57
doi: 10.29244/jji.v11i1.394

Molecular Docking of Active Compound of Okra (Abelmoschus esculentus L.) on α-Glucosidase as Antidibetic Mellitus Drug Candidate
type: item
description: Diabetes mellitus (DM) is a leading cause of death among degenerative diseases, primarily due to impaired insulin function that disrupts carbohydrate metabolism. One therapeutic strategy involves α-glucosidase inhibitors that delay glucose absorption. Abelmoschus esculentus (okra) is rich in phenolic and flavonoid compounds with antihyperglycemic and antioxidant activity, suggesting potential as α-glucosidase inhibitors. This study evaluated the inhibitory potential of okra-derived compounds against α-glucosidase using in silico molecular docking with PLANTS and YASARA Structure. The analysis included physicochemical screening, ligand–receptor preparation, and docking simulations, assessing docking score, Gibbs free energy (ΔG), and dissociation constant (Kd). Cannabiscitrin, a flavonoid from okra, demonstrated the strongest binding affinity, outperforming the reference drug acarbose in all parameters. These findings suggest its potential as an alternative antidiabetic agent.
subject: Articles
  topic: section
subject: α-glucosidase
  topic: keywords
subject: Diabetes
  topic: keywords
subject: Docking
  topic: keywords
subject: Flavonoids
  topic: keywords
subject: Okra
  topic: keywords
creator: Shobiroh Nuur'Alimah
creator: Laksmi Ambarsari
creator: Muhammad Farhan
rights: Copyright (c) 2026 Jurnal Jamu Indonesia
date: 2026-02-06
publication date: 2026-02-06
starting page: 1
ending page: 11
doi: 10.29244/jji.v11i1.360

Antibacterial Activity of Esterified Trigona laeviceps Hive Waste Extract against Skin-Associated Bacteria
type: item
description: Stingless bee (Trigona laeviceps) hive waste contains bioactive compounds, including flavonoids, phenolics, terpenoids, and organic acids, with potential antibacterial activity. This study aimed to enhance its antibacterial activity through esterification using methanol and ethanol. The extract was obtained by sonochemical extraction with 96% ethanol and reacted with methanol or ethanol using H₂SO₄ as a catalyst. Esterification products were characterized by FTIR and GC–MS. Antibacterial activity against Staphylococcus aureus and Propionibacterium acnes was evaluated at 10%, 15%, and 20% using the agar well-diffusion method. Alcohol variation affected the chemical profile and antibacterial activity. The ethanol ester showed the largest inhibition zones at 20%, measuring 1.97 ± 0.24 mm against S. aureus and 1.90 ± 0.10 mm against P. acnes. These findings suggest that esterification may improve the value of stingless bee hive waste as a natural antibacterial candidate.
subject: Articles
  topic: section
subject: Antibacterial activity
  topic: keywords
subject: Esterification
  topic: keywords
subject: Hive waste
  topic: keywords
subject: Propionibacterium acnes
  topic: keywords
subject: Staphylococcus aureus
  topic: keywords
creator: Mighfar Syukur
creator: Ahmad Fuad Masduqi
creator: Yuliana
rights: Copyright (c) 2026 Jurnal Jamu Indonesia
date: 2026-05-26
publication date: 2026-05-26
starting page: 174
ending page: 183
doi: 10.29244/jji.v11i3.446

Table of Contents
type: item
description: Table of Contents
subject: Articles
  topic: section
creator: Jurnal Jamu Indonesia JJI
rights: Copyright (c) 2025 Jurnal Jamu Indonesia
date: 2025-09-15
publication date: 2025-09-15
doi: 10.29244/jji.v10i3.440

Evaluation of the Antibacterial Activity of Muntingia calabura L. Leaf Extract in Anti-Acne Serum and Gel Moisturizer Formulations
type: item
description: The cherry tree (Muntingia calabura L.) is known to contain bioactive compounds such as flavonoids, tannins, and saponins, which exhibit potential as natural antibacterial agents against acne-causing bacteria. This study aimed to evaluate and compare the antibacterial efficacy of serum and moisturizer gel formulations containing ethanol extract of M. calabura leaves against Propionibacterium acnes. Serum was selected due to its high concentration of active ingredients and superior skin penetration, while the gel moisturizer provides a light, non-greasy texture that is comfortable and easily absorbed. The results demonstrated that the serum formulation containing 18% extract (F3) exhibited the highest antibacterial activity against P. acnes, with a strong inhibition zone. Similarly, the gel formulation with 6% extract (F3) also showed a strong inhibitory effect. These findings highlight the potential of M. calabura leaf extract as an effective natural agent for the development of topical anti-acne skincare products.
subject: Communication
  topic: section
subject: Anti-acne
  topic: keywords
subject: Gel moisturizer
  topic: keywords
subject: Muntingia calabura L.
  topic: keywords
subject: Propionibacterium acnes
  topic: keywords
subject: Serum
  topic: keywords
creator: Andi Ulfah Magefirah Rasyid
creator: Nurfadilah Nurfadilah
creator: Fityatun Usman
creator: Zulkifli Zulkifli
creator: Zulham Zulham
creator: Asril Burhan
rights: Copyright (c) 2026 Jurnal Jamu Indonesia
date: 2026-02-06
publication date: 2026-02-06
starting page: 12
ending page: 17
doi: 10.29244/jji.v11i1.413

Cytotoxic Effect of Brazilin on DU145 Prostate Cancer Cells Using the WST-8 Assay
type: item
description: Prostate cancer is characterized by abnormal growth of prostate gland cells due to uncontrolled cellular proliferation. Brazilin, a homoisoflavonoid compound derived from Caesalpinia sappan L., is known for its anticancer activity. This study aimed to evaluate the cytotoxic effect of brazilin on DU145 prostate cancer cells through an in vitro assay employing the WST-8 method. The results showed that both brazilin and cisplatin significantly reduced the cancer cell survival rate compared to the negative control group (p < 0.05). Although no significant difference was observed between the two compounds at the highest concentration (ns), their IC₅₀ values differed significantly (p < 0.05), recorded at 18.92 ppm for brazilin and 0.03569 ppm for cisplatin; both were classified as highly active. These findings suggest that brazilin possesses cytotoxic potential comparable to cisplatin at elevated concentrations and may be developed further as a naturally derived anticancer agent.
subject: Communication
  topic: section
subject: Brazilin
  topic: keywords
subject: Cytotoxicity
  topic: keywords
subject: Prostate cancer
  topic: keywords
subject: DU145
  topic: keywords
subject: WST-8
  topic: keywords
creator: Syafika Alaydrus
creator: Niluh Puspita Dewi
creator: Dinda Pratiwi
rights: Copyright (c) 2026 Jurnal Jamu Indonesia
date: 2026-02-06
publication date: 2026-02-06
starting page: 48
ending page: 51
doi: 10.29244/jji.v11i1.423

Optimizing Ultrasonic Extraction of Enhalus acoroides to Enhance Physicochemical Traits and Antioxidant Activity
type: item
description: Enhalus acoroides is a seagrass species known for its antioxidant potential due to its flavonoid content, including quercetin. This study aimed to optimize the extraction time using the ultrasound-assisted extraction (UAE) method based on physicochemical parameters and antioxidant activity. The simplicia was extracted for 20, 30, and 40 minutes, each in triplicate, using 96% ethanol acidified with 1% HCl. The results demonstrated that extraction time significantly influenced the physicochemical properties, including yield (highest at 30 minutes: 40.2%), total phenolic content (1.153 mg GAE/g), total flavonoid content (0.318 mg QE/g), quercetin content (0.316 mg/g), and antioxidant activity (IC₅₀ = 58.44 ppm), whereas no significant effect was observed on total ash content. Qualitative phytochemical screening revealed the presence of alkaloids, flavonoids, tannins, saponins, and triterpenoids. Based on these findings, a 30-minute extraction time is recommended as the optimal condition for obtaining E. acoroides extract with the highest antioxidant activity.
subject: Articles
  topic: section
subject: Antioxidant
  topic: keywords
subject: Enhalus acoroides
  topic: keywords
subject: Flavonoid
  topic: keywords
subject: Ultrasound Assisted Extraction
  topic: keywords
creator: Siti Mardiyanti
creator: Effionora Anwar
creator: Yesi Desmiaty
creator: Siti Sadiah
rights: Copyright (c) 2025 Jurnal Jamu Indonesia
date: 2025-09-15
publication date: 2025-09-15
starting page: 138
ending page: 144
doi: 10.29244/jji.v10i3.419

Specific and Non-Specific Safety Testing of Red Gedi Leaf Ethanol Extract (Abelmoschus manihot L. Medik)
type: item
description: Red gedi leaves (Abelmoschus manihot (L.) Medik) are traditionally used for their antidiabetic, antioxidant, and hepatoprotective properties. This study aimed to characterize the specific and non-specific quality parameters of red gedi leaf ethanol extract based on Herbal Pharmacopoeia standards. Extraction was performed by maceration using 96% ethanol, yielding 6.72%. Phytochemical screening confirmed the presence of flavonoids, saponins, tannins, quinones, and steroids, with a high total flavonoid content of 56.97 ± 3.75 mg/g. Non-specific parameters, including water content, drying loss, ash values, microbial contamination, and heavy metal levels (Pb and Cd), complied with the required standards. Organoleptic evaluation showed a viscous extract with brownish color, slightly astringent taste, and characteristic odor. These results indicate that red gedi leaf ethanol extract meets Herbal Pharmacopoeia quality requirements and has potential for development as a standardized antioxidant herbal product.
subject: Articles
  topic: section
subject: Abelmoschus manihot
  topic: keywords
subject: Ethanol extract
  topic: keywords
subject: Flavonoids
  topic: keywords
subject: Red gedi
  topic: keywords
creator: Joni Tandi
creator: Yuliet Susanto
creator: Tien Wahyu Handayani
creator: Magfirah Magfirah
creator: Muthmainah Tuldjanah
rights: Copyright (c) 2026 Jurnal Jamu Indonesia
date: 2026-02-06
publication date: 2026-02-06
starting page: 58
ending page: 65
doi: 10.29244/jji.v11i1.417

Phytochemical Screening and Antibacterial Activity of Jackfruit Seed Extract (Artocarpus heterophyllus Lamk.) Against Salmonella typhi In Vitro
type: item
description: Salmonella typhi infection remains a public health concern, necessitating natural treatment alternatives. This study aimed to evaluate the antibacterial activity and identify the active compounds of jackfruit seed (Artocarpus heterophyllus Lamk) ethanol extract against S. typhi in vitro. Antibacterial activity was tested using the well diffusion method at extract concentrations of 25%, 50%, 75%, and 100%, with chloramphenicol and 10% DMSO as positive and negative controls. All extract concentrations produced significant inhibition zones (mean: 19.83 mm to 31.42 mm; p<0.05). Phytochemical screening revealed flavonoids, alkaloids, steroids, and saponins as the active compounds. Antibacterial efficacy increased with concentration and was comparable to chloramphenicol (mean: 33.49 mm). These results indicate that jackfruit seed extract holds promise as a natural antibacterial agent against S. typhi.
subject: Articles
  topic: section
subject: Jackfruit seed extract
  topic: keywords
subject: Artocarpus heterophyllus
  topic: keywords
subject: Antibacterial
  topic: keywords
subject: Salmonella typhi
  topic: keywords
subject: Pytochemical screening
  topic: keywords
creator: Ami Febriza
creator: Salwa Amalia Kartika
creator: Asdar
rights: Copyright (c) 2025 Jurnal Jamu Indonesia
date: 2025-09-15
publication date: 2025-09-15
starting page: 126
ending page: 131
doi: 10.29244/jji.v10i3.400

Metabolite Profiling and Bioactivity Assessment of Antioxidant and Antibacterial Properties in Bulb Fractions of Eleutherine bulbosa (Mill.) Urb
type: item
description: Eleutherine bulbosa is known to contain diverse secondary metabolites with pharmacological potential. This study aimed to identify the bioactive compounds in the ethanol, n-hexane, and unsaponified n-hexane fractions of E. bulbosa bulbs and evaluate their antioxidant and antibacterial activities. The bulbs were extracted using ethanol, followed by n-hexane fractionation and saponification. Antioxidant activity was determined using the DPPH assay, and antibacterial activity was assessed against Staphylococcus aureus and Escherichia coli using the disc diffusion method. LC-MS/MS and GC-MS analyses identified compounds such as eleutherol, resveratrol, coniferaldehyde, and stigmasterol. The ethanol fraction exhibited the highest antioxidant activity (IC₅₀ = 47.54 ± 0.03 mg/L), while the unsaponified n-hexane fraction showed the strongest antibacterial effect (inhibition zone = 16.12 ± 0.16 mm). These findings confirm the potential of E. bulbosaas a natural source of antioxidant and antibacterial agents.
subject: Articles
  topic: section
subject: Eleutherine bulbosa
  topic: keywords
subject: Antioxidant
  topic: keywords
subject: Antibacterial
  topic: keywords
subject: Metabolite profiling
  topic: keywords
subject: Natural product
  topic: keywords
creator: Nurma Angeliani Komalasari
creator: Natalia Natalia Marbun
creator: Gustini Syahbirin
creator: Laksmi Ambarsari
creator: Purwatiningsih Sugita
rights: Copyright (c) 2026 Jurnal Jamu Indonesia
date: 2026-02-06
publication date: 2026-02-06
starting page: 28
ending page: 38
doi: 10.29244/jji.v11i1.388

In Silico Evaluation of Flavonoids from Imperata cylindrica as Potential Antidiabetic Agents
type: item
description: Diabetes mellitus is a metabolic disorder characterized by impaired insulin secretion and disrupted blood-glucose homeostasis. Novel therapies targeting the incretin system, such as dipeptidyl peptidase 4 (DPP-4) inhibitors, enhance insulin secretion, protect β-pancreatic cells, and restore glucose balance. Imperata cylindrica (reeds) has shown antidiabetic effects, including improved insulin release and reduced blood glucose, but its molecular mechanism remains unclear. This study investigated flavonoid compounds from I. cylindrica as potential DPP-4 inhibitors using molecular docking. The target protein (PDB: 6B1E) and drug-like flavonoids were evaluated via PyRx and visualized with Discovery Studio 2021. The results indicate that tricin binds strongly to DPP-4 (−8.4 kcal/mol) and forms stable interactions with residues ILEB102, ILEB76, and ILEB529. These findings suggest that tricin from I. cylindrica may inhibit DPP-4 and serve as a potential antidiabetic agent in silico.
subject: Articles
  topic: section
subject: Diabetes mellitus
  topic: keywords
subject: DPP-4
  topic: keywords
subject: Flavonoid
  topic: keywords
subject: Imperata cylindrica
  topic: keywords
subject: Molecular docking
  topic: keywords
creator: Moh. Royhan Afnani
creator: Riska Ayu Sutriyansyah
creator: Arif Nur Muhammad Ansori
rights: Copyright (c) 2026 Jurnal Jamu Indonesia
date: 2026-02-06
publication date: 2026-02-06
starting page: 18
ending page: 27
doi: 10.29244/jji.v11i1.404

Optimizing Curcumin SNEDDS via D-Optimal Design and Evaluating Wound Healing Efficacy in Wistar Rats
type: item
description: Curcumin, a bioactive compound extracted from turmeric, exhibits extensive pharmacological properties, including anti-inflammatory and wound-healing activities. Nevertheless, its clinical application is hindered by low aqueous solubility and poor bioavailability. This study aimed to optimize a curcumin-loaded Self-Nanoemulsifying Drug Delivery System (SNEDDS) using a D-Optimal experimental design to improve its solubility, stability, and therapeutic efficacy. The SNEDDS formulation was developed by varying the proportions of oil, surfactant, and co-surfactant. The optimized formulation demonstrated a particle size of 120 nm and an encapsulation efficiency of 94.5%, significantly accelerating wound closure by 98% within 14 days in Wistar rats. These results highlight the potential of curcumin SNEDDS as an effective topical formulation for wound therapy.
subject: Articles
  topic: section
subject: Curcumin
  topic: keywords
subject: D-Optimal
  topic: keywords
subject: Nanoemulsion
  topic: keywords
subject: SNEDDS
  topic: keywords
subject: Wound healing
  topic: keywords
creator: Ferdinta Daniasta Setyawan
creator: Herman
creator: Farhan Imba
rights: Copyright (c) 2025 Jurnal Jamu Indonesia
date: 2025-09-15
publication date: 2025-09-15
starting page: 171
ending page: 175
doi: 10.29244/jji.v10i3.393

Ethnopharmacological Study of Medicinal Plants Used by the Dayak Tunjung Benuaq Tribe in East Kalimantan, Indonesia
type: item
description: Ethnopharmacology is a scientific approach used to document traditional knowledge regarding the use of medicinal plants. The Dayak Tunjung Benuaq Tribe in Putak Village, East Kalimantan, Indonesia, continues to rely on herbal remedies for treating various ailments. This study aimed to identify plant species used, their therapeutic applications, and preparation methods. Data were collected through purposive and snowball sampling techniques, using semi-structured interviews with knowledgeable informants. Quantitative analysis was performed using Use Value (UV), Informant Consensus Factor (ICF), and Fidelity Level (FL). A total of 31 species from 19 families were recorded, including Carica papaya, Zingiber officinale, Psidium guajava, and Eleutherine bulbosa. Leaves were the most commonly used plant part (58%), most often prepared by boiling (93.6%) and administered orally (93.6%). C. papaya had the highest UV (0.23), while seven disease categories, such as malaria, fever, and joint pain, achieved perfect consensus (ICF = 1.0). Several species, including E. bulbosa and Syzygium polyathum, reached 100% FL, reflecting strong cultural preference for specific treatments. These findings emphasize the significance of traditional knowledge within the community, the need for documentation and preservation, and the potential of these plants for future pharmacological exploration and biodiversity conservation.
subject: Articles
  topic: section
creator: Reza Nur Fadhillah
creator: Paula Mariana Kustiawan
rights: Copyright (c) 2025 Jurnal Jamu Indonesia
date: 2025-09-15
publication date: 2025-09-15
starting page: 182
ending page: 188
doi: 10.29244/jji.v10i3.376

In Silico Exploration of Orthosiphon stamineus Compounds as Potential Angiotensin Receptor Blockers for Hypertension Therapy
type: item
description: Orthosiphon stamineus has demonstrated antihypertensive potential, but the specific bioactive compounds involved remain unclear. This study aimed to evaluate selected phytochemicals from O. stamineus as angiotensin receptor blockers (ARBs) targeting protein 4ZUD using in-silico methods. Molecular docking was conducted to assess binding affinity, while ADMET analysis evaluated pharmacokinetics and toxicity. Salvianolic acid E showed the strongest binding affinity with a rerank score of −134.02 kcal/mol, surpassing olmesartan (−124.52 kcal/mol). Key interactions were observed with amino acid residues Arg167, Tyr92, and Asp281. ADMET predictions revealed that Salvianolic acid E has good aqueous solubility, moderate intestinal absorption (HIA 45.99%), and low membrane permeability (Caco-2 < 0.4). It does not inhibit major cytochrome P450 isoenzymes and is predicted to be non-hepatotoxic, suggesting favorable safety and metabolic profiles. These findings highlight Salvianolic acid E as a promising phytochemical candidate for antihypertensive drug development.
subject: Articles
  topic: section
subject: Angiotensin receptor blocker
  topic: keywords
subject: Antihypertensive agent
  topic: keywords
subject: In-silico
  topic: keywords
subject: Orthosiphon stamineus
  topic: keywords
subject: Salvianolic acid E
  topic: keywords
creator: Andri Prasetiyo
creator: Aqilah Idelia Indriani
creator: Karina Natasya Ramadhani
creator: Amitta Natthawani
creator: Islami Al-Kaffah Ramadhan
creator: Amira Thufailla Yogaswara
creator: Cresentia Audrey
creator: Esti Mulatsari
creator: Esti Mumpuni
creator: Nurulita Az Zahra
rights: Copyright (c) 2025 Jurnal Jamu Indonesia
date: 2025-09-15
publication date: 2025-09-15
starting page: 176
ending page: 181
doi: 10.29244/jji.v10i3.370