Jurnal Jamu Indonesia

2024-07-04T13:55:03+07:00

Combination Effects of African Leaf Ethanol Extract (Vernonia amygdalina Del.) with Red Onion Peel (Allium cepa L.) as Antidiabetes in Streptozotocin-induced Mice

2024-01-11T15:40:59+07:00

Type 2 diabetes arises when the body becomes resistant to insulin or when the pancreas fails to produce sufficient insulin. This study aimed to evaluate the antidiabetic effects of reducing blood glucose levels in white male mice through the administration of an ethanol extract of African leaves and onion peel, as well as to determine the duration of these effects. Streptozotocin was used to induce diabetes in the mice, and the experiment was conducted over a period of 21 days. The mice were divided into seven groups: Group 1 received a placebo (CMC Na 0.5%), Group 2 received glibenclamide (0.013 mg/20 g body weight), Group 3 received a single dose of African leaf extract (4.2 mg/20 g BW), Group 4 received a single dose of onion peel extract (4 mg/20 g BW), and Groups 5, 6, and 7 received combinations of African leaf and onion peel extracts at ratios of 1:1, 1:2, and 2:1, respectively. The results demonstrated that the combined administration of African leaf and onion peel extracts significantly reduced blood glucose levels, with decreases of 44.701%, 49.929%, and 51.996% in the 1:1, 1:2, and 2:1 group, respectively. The 1:1 combination was particularly effective, showing a reduction in blood glucose levels comparable to the positive control, which achieved a 45.957% decrease. The administration of the test preparations effectively reduced blood glucose levels over 21 days, with significant reductions observed on both the 14th and 21st days.

Growth, Phenolic, and Flavonoid Production of Adenostemma platyphyllum at Different Dosages of Cow Manure

2024-02-29T18:55:23+07:00

Adenostemma platyphyllum is a weed plant containing various secondary metabolites, such as phenolics and flavonoids, making it essential to cultivate properly. This study aims to determine the optimal cow manure dosage for plant growth, focusing on phenolic and flavonoid production in the cultivation of A. platyphyllum. The experiment employed a randomized complete block design (RCBD) with a single factor: cow manure doses of 0.5, 5, 10, 15, and 20 ton/Ha. Phenolic content was measured using the Folin Ciocalteu reagent, while flavonoid content was assessed using the AlCl₃ reagent. Results indicate that the highest phenolic and flavonoid production occurred in plants treated with 20 ton/Ha manure. This dosage also resulted in the best plant growth, yielding the highest crop, number of leaves, and branches compared to other treatments.

Patterns and Marketing Strategies of Herbal Medicine at Sukoharjo Regency

2024-04-28T17:47:23+07:00

The development of the herbal industry, especially in the sector of herbal medicine, is increasingly gaining momentum. The COVID-19 pandemic has heightened the demand for a healthy life. Consequently, many institutions are involved in the marketing and distribution of herbal products. This study aimed to analyze the institutions involved, marketing patterns, and marketing strategies for industrially processed herbal medicine products. A qualitative approach with descriptive analysis was employed in this study. Data collection methods included observation, literature study, and interviews with informants. The key informants in this research included herbal medicine business actors and market managers. These business actors consist of herbal medicine processors and marketers. This research was conducted in Sukoharjo Regency. The results show that the institutions involved in the marketing chain of herbal medicine products comprise raw material suppliers, manufacturers functioning as distributors, retailers, and consumers. The marketing chain for processed herbal medicine products can be categorized into 6 marketing channels. The marketing strategies for industrially processed herbal medicine products that can be implemented include promotion via social media; employing a super value strategy; adding distribution agents; developing research on standardization and market opportunities; and innovation in industrially processed herbal medicine products.

Antioxidant Activities Of Various Fraction Levels Of Kaik Kaik (Uruparia Multiflora K.Schum. & Lauterb)

2024-01-08T13:35:52+07:00

Borneo has abundant biodiversity, especially regarding medicinal plants. One of the plants used in traditional medicine by the Dayak tribe in Kalimantan is kaik-kaik (Uncaria cordata (Lour.) Merr.), so research is needed to evaluate the activity of this plant. One of the methods used to assess its medicinal properties is through its antioxidant activity. This research aimed to test the antioxidant activity of various fractions derived from U. cordata stems. The study began with ethanol extraction followed by fractionation using n-hexane, ethyl acetate, and distilled water. The extracts and fractions obtained were then tested for antioxidant activity using the DPPH radical capture method. The results indicated that the n-hexane fraction, with a yield of 0.69%, contains terpenoids/steroids, alkaloids, and flavonoids; the ethyl acetate fraction, with a yield of 1.453%, contains alkaloids and flavonoids; and the distilled water fraction, with a yield of 4.832%, contains saponins, tannins, alkaloids, phenols, and flavonoids. The n-hexane, ethyl acetate, and distilled water fractions exhibited antioxidant capacity with IC₅₀ values of 138.39 ± 0.3777 ppm, 48.51 ± 0.056 ppm, and 36.31 ± 0.111 ppm, respectively. This research concluded that the distilled water fraction was the most active and is classified as a very strong antioxidant.

Optimization of Flocel 101 and Amylum as Fillers in Sambiloto (Andrographis paniculata (Burm.f.) Nees.) Capsules Formulation

2024-05-13T10:35:01+07:00

Sambiloto (Andrographis paniculata (Burm.f.) Nees.) is an herbal plant that is beneficial for health due to its main chemical component, andrographolide. Sambiloto can be formulated into capsules to make it more practical and comfortable for consumption, mask the bitter taste, and guarantee dosage accuracy. This research aimed to determine the optimal concentration of Flocel 101 and amylum as capsule fillers to achieve the best physical properties of Sambiloto extract capsules. The study was conducted experimentally using 5 (five) formulas (F1, F2, F3, F4, and F5) with various concentrations of Flocel 101 and amylum. A series of tests were conducted on the physical properties of the capsule powder: organoleptic tests, water content, flowability, disintegration time, and average capsule weight. Additionally, quality control was performed by checking for microbial contamination through total plate count (TPC) and yeast and mold count (YMC) tests. The results of this research indicated that the F1 formula provided the best physical properties and met the requirements, with the appearance of a greenish-gray dry powder, water content of 6.88%, flow rate of 20 g/s, disintegration time of 15.5 minutes, average weight of 0.55 g, TPC 250 cfu/g, and YMC <10 cfu/g.

Network Pharmacology Approach to Explore Active Compounds and Molecular Mechanisms of Jamu

2024-08-11T00:34:12+07:00